Carvedilol phosphate hemihydrate

SKU: orb1310705

Description

Carvedilol phosphate hemihydrate is the phosphate salt of the racemic adrenergic antagonist carvedilol, which lacks intrinsic sympathomimetic activity. This compound is widely used in cardiovascular research, including in vitro receptor binding studies and in vivo models of hypertension and heart failure.

Research Area

Cardiovascular Research, Cell Biology, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 610309-89-2
• MW: 513.49
• Purity: 100.00% (May vary between batches)
• Formula: C₂₄H₂₆N₂O₄·0.5 H₂O·H₃O₄P
• SMILES: O.OP(O)(O)=O.OP(O)(O)=O.COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12.COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12
• Target: NADPH|||Integrin|||Adrenergic Receptor|||VEGFR|||Potassium Channel|||LDL|||Gap Junction Protein|||Autophagy
• Solubility: DMSO:245 mg/mL (477.13 mM)

Bioactivity

• Target IC50:
  LDL oxidation:3.8 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

β/α-1, VCAM1, VEGFR, Potassium Channel, PotassiumChannel, peroxidation, antihypertensive, angina, Autophagy, Carvedilol phosphate, Carvedilol Phosphate, Carvedilol phosphate hemihydrate, Carvedilol phosphate Hemihydrate, BM 14190, BM 14190 (phosphate hemihydrate), BM 14190 phosphate hemihydrate, BM14190, BM-14190, blocker, Adrenergic Receptor, AdrenergicReceptor, congestive, Beta Receptor, E-selectin, failure, Inhibitor, Gap Junction Protein, GapJunctionProtein, heart, LDL, NLRP3, Natriuretic peptides B, NADPH dehydrogenase, inflammasome, inhibit, lipid

Compound Identifiers

PubChem CID

11954344