Carprofen

SKU: orb1308975

Description

Carprofen

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 53716-49-7
• MW: 273.71
• Purity: 98.99%
• Formula: C₁₅H₁₂ClNO₂
• SMILES: ClC=1C=C2C=3C(NC2=CC1)=CC(C(C(O)=O)C)=CC3
• Target: Autophagy,FAAH,COX,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.61 mM);Ethanol:51 mg/mL (186.33 mM);DMSO:123 mg/mL (449.38 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  COX-2 (canine):30 nM|FAAH:78.6 μM|COX-1:22.3 μM
• In Vivo:
  Carprofen binds to human serum albumin (HSA) via fluorescence and equilibrium dialysis methods, with two sets of binding constants [K1=5.1 μM (fluorescence) and 3.7 μM (ED), K2=37 μM (fluorescence) and 13 μM (ED)]. It predominantly binds to site II, the benzodiazepine site, while site I, the Warfarin site, exhibits a lower affinity for Carprofen. The carboxyl group of Carprofen plays a significant role in its high-affinity binding with HSA. Additionally, Carprofen (S and R enantiomers) inhibits canine COX2 with an IC50 of 0.102 microM, primarily attributed to the S enantiomer (IC50, 0.0371 μM), which is approximately 200 times more potent than the R enantiomer (IC50, 5.97 microM).
• In Vitro:
  Administration of 4 mg/kg Carprofen significantly elevated peak plasma concentrations in dogs. Compared to buprenorphine, Carprofen treatment resulted in marginally superior analgesic effects with reduced sedative action in canines. Preoperative administration of Carprofen in dogs yielded lower pain scores than other groups, with marked effectiveness observed 2 hours post-extubation. Carprofen provided sustained analgesia for 18 hours in treated canines without adverse side effects and notably improved the speed of recovery in limping birds.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Carprofen, COX-2, COX, Imadyl, FAAH, Fatty acid amide hydrolase, Ridamyl, Rimadyl

Compound Identifiers

PubChem CID

2581