Carnosol

SKU: orb1221988

Description

Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer cells to chemotherapeutic agents. Carnosol may as a novel agonist of TRPA1 with an EC5 value of 12.46 µM.

Key Properties

• CAS Number: 5957-80-2
• MW: 330.42
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₆O₄
• SMILES: CC(C)C1=C(C(=C2C(=C1)C3CC4C2(CCCC4(C)C)C(=O)O3)O)O
• Target: Others
• Solubility: DMSO : ≥ 125 mg/mL; 378.31 mM

Bioactivity

• In Vivo:
  Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged.
• In Vitro:
  It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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