Cariprazine

SKU: orb1302742

Description

Cariprazine (RGH-188) is a research antipsychotic candidate with sub-nanomolar affinity for dopamine D3 and D2 receptors, along with moderate 5-HT1A receptor binding. It is utilized in preclinical in vitro and in vivo studies investigating dopamine receptor pharmacology and potential therapeutic mechanisms for psychiatric disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 839712-12-8
• MW: 427.41
• Purity: 99.87%
• Formula: C₂₁H₃₂Cl₂N₄O
• SMILES: CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cccc(Cl)c2Cl)CC1
• Target: 5-HT Receptor,Dopamine Receptor
• Solubility: DMSO:Slightly soluble

Bioactivity

• Target IC50:
  5-HT1A receptor:2.6 nM|D2 receptor:0.49 nM |D3 receptor:0.085 nM

Storage & Handling

• Storage: store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DopamineReceptor, Dopamine Receptor, Dopamine, D3, D2, Cariprazine, 5HTReceptor, 5-hydroxytryptamine Receptor, 5-HT1A, 5-HT Receptor, 5HT Receptor, Inhibitor, inhibit, Serotonin Receptor, RGH188, RGH-188, RGH 188

Compound Identifiers

PubChem CID

11154555