Carfilzomib

SKU: orb1223803

Description

A potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM; weakly inhibits caspase-like and trypsin-like activities in cellular assays (IC50150-200 nM), also inhibits the chymotrypsin-like activity of the immunoproteasome (IC50=33 nM); accumulates proteasome substrates and induces cell cycle arrest and/or apoptosis; shows antitumor efficacy in vivo.Blood Cancer Approved.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 868540-17-4
• MW: 719.9099
• Purity: >98% (HPLC)
• Formula: C₄₀H₅₇N₅O₇
• SMILES: CC(C)C[C@H](NC([C@@H](NC(CN1CCOCC1)=O)CCC2=CC=CC=C2)=O)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(C)C)C([C@]4(C)OC4)=O)=O)=O.
• Target: Proteasome
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PR 171 | PR171 | PR-171

Quick Database Links

Gene Symbol

Proteasome