Cardiogenol C hydrochloride

SKU: orb1299306

Description

Cardiogenol C hydrochloride is a small molecule that promotes the differentiation of embryonic stem cells (ESCs) into cardiomyocytes, exhibiting an EC50 of 100 nM. This compound is a valuable tool for in vitro cardiac differentiation studies and research in regenerative medicine and developmental biology.

Research Area

Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1049741-55-0
• MW: 296.75
• Purity: >99.99% (May vary between batches)
• Formula: C₁₃H₁₇ClN₄O₂
• SMILES: Cl.COc1ccc(Nc2nccc(NCCO)n2)cc1
• Target: Wnt/beta-catenin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.74 mM);H2O:2 mg/mL (6.74 mM);DMSO:70 mg/mL (235.89 mM)

Bioactivity

• Target IC50:
  Differentiation of ESCs into cardiomyocytes:100 nM (EC50)
• In Vitro:
  Cardiogenol C could induce HBPCs to express transcription factors GATA4, Nkx2.5 and Tbx5, which are early specific markers for pre-cardiomyogenic cells.
• Cell Research:
  Used GMEM plus 5 μM Cardiogenol C and 7.5% ESQ-FBS. The cultures were harvested at different day-intervals after induction for immunohistochemistry, semi-quantitative RT-PCR analysis, western blot analysis and comparative proteomic.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

esc, pyrimidine, MHC, betacatenin, beta-catenin, Cardiomyogenic, Cardiogenol C HCl, bcatenin, transplantation,?progenitor, βcatenin, β-catenin, stem, plasticity, Wnt/β-catenin, Wnt/b-catenin, Wnt/betacatenin, Wnt

Compound Identifiers

PubChem CID

16078958