Carboxyebselen

SKU: orb1691626

Description

Carboxyebselen (HOOC-Ebs) is a potent and selective inhibitor of endothelial nitric oxide synthase (eNOS). It is a valuable research tool for studying nitric oxide signaling pathways in both cellular (in vitro) and animal (in vivo) models of vascular biology and related diseases.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 153871-75-1
• MW: 318.19
• Purity: 97.05% (May vary between batches)
• Formula: C₁₄H₉NO₃Se
• SMILES: O=C1N([Se]C=2C1=CC=CC2)C3=CC=C(C(O)=O)C=C3
• Target: NOS
• Solubility: DMSO:55 mg/mL (172.85 mM)

Bioactivity

• In Vivo:
  Carboxyebselen (HOOC-Ebs) inhibits NOS present in enzymatic preparations from bovine endothelium, porcine cerebella, and murine spleen. HOOC-Ebs (0.1-30 μM) causes a concentration-dependent endothelium-independent relaxation of rings of rabbit aorta.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Carboxyebselen, HOOC-Ebs, eNOS

Compound Identifiers

PubChem CID

192654