Capromorelin Tartrate

SKU: orb1218538

Description

Capromorelin Tartrate is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a).(In Vitro):Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM.(In Vivo):Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv.

Key Properties

• CAS Number: 193273-69-7
• MW: 655.7
• Purity: >98% (HPLC)
• Formula: C₃₂H₄₀N₅O₁₀
• SMILES: O=C([C@@H]([C@@H](O)C(O)=O)O)O.CC(C)(N)C(N[C@H](COCC1=CC=CC=C1)C(N(C[C@]23CC4=CC=CC=C4)CCC2=NN(C)C3=O)=O)=O
• Target: GHSR
• Solubility: DMSO:100 mg/mL (152.51 mM)

Bioactivity

• In Vivo:
  Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat) = 65%, F(dog) = 44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv.
• In Vitro:
  Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP 424391-18

Quick Database Links

Gene Symbol

GHSR