Capmatinib xHCl

SKU: orb1298952

Description

Capmatinib hydrochloride (INCB28060) is a potent, selective, and orally bioavailable ATP-competitive inhibitor of c-Met kinase. It demonstrates low nanomolar IC50 values in biochemical and cellular assays, effectively blocking both constitutive and HGF-stimulated c-Met activity. This inhibitor is widely used in cancer research, particularly for studying c-Met-dependent tumor models in vitro and in vivo.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1029714-89-3
• MW: 448.89
• Purity: 99.24% (May vary between batches)
• Formula: C₂₃H₁₈ClFN₆O
• SMILES: Cl.CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
• Target: c-Met/HGFR
• Solubility: DMSO:4.49 mg/mL (10 mM)

Bioactivity

• In Vitro:
  Capmatinib hydrochloride blocks cell proliferation and migration or induces apoptosis in different types of cancer cells

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cMet/HGFR, c-Met/HGFR, c-Met, cMet, Apoptosis, ATP competitive, Capmatinib, Capmatinib hydrochloride(free base), Capmatinib xHCl, Balb/c nu/nu mice, inhibit, INC 280, INC-280, INC280, INCB 28060, INCB28060, INCB-28060, Inhibitor, H441, HGFR, orally active, S114, SNU-5, U-87MG

Compound Identifiers

PubChem CID

137347172