Capecitabine-2',3'-cyclic Carbonate

SKU: orb1685728

Description

Capecitabine-2',3'-cyclic Carbonate is a prodrug derivative of the antimetabolite capecitabine, functioning as an antiproliferative agent. It is utilized in cancer research, particularly for studying colorectal and breast cancer models, to investigate its metabolism and cytotoxic effects in both in vitro and in vivo experimental settings.

Key Properties

• CAS Number: 921769-65-5
• MW: 385.34
• Purity: 99.72%
• Formula: C₁₆H₂₀FN₃O₇
• SMILES: O=C1N([C@H]2[C@]3([C@@]([C@@H](C)O2)(OC(=O)O3)[H])[H])C=C(F)C(NC(OCCCCC)=O)=N1
• Target: Others
• Solubility: DMSO:27.5 mg/mL (71.37 mM)

Bioactivity

• In Vitro:
  Capecitabine-2',3'-cyclic Carbonate inhibits the proliferation of tumor cells with IC50 of 0.08mg/mL, 0.08mg/mL, 0.14mg/mL and 0.18mg/mL for HeLa, MCF-7, PZ-HPV-7 and NCI-69, respectively.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

58434491