Canrenone

SKU: orb1223493

Description

A synthetic pregnadiene compound with anti-aldosterone activity.(In Vitro):Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner. Canrenone dose-dependently reduces platelet-derived growth factor–induced cell proliferation and motility. Canrenone inhibits the activity of the Na+/H+ exchanger 1 induced by platelet-derived growth factor.(In Vivo):Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone.

Key Properties

• CAS Number: 976-71-6
• MW: 340.46
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₈O₃
• SMILES: O=C1CC[C@]2(CO3)C4CC[C@]5(C3=O)[C@](O)(CCC(O)=O)CC[C@@]5([H])[C@]4([H])C=CC2=C1
• Target: GR
• Solubility: DMSO: > 10 mM

Bioactivity

• In Vivo:
  Canrenone is the principal active metabolite of Spironolactone in the rat only for a limited period. During chronic treatment a difference developed between the effect of Spironolactone and Canrenone on the RAAS indicating a decrease in the anti-mineralocorticoid activity of Canrenone and an increase in the efficacy of Spironolactone.
• In Vitro:
  Canrenone inhibits the production of eortieosterone, 18-hydroxydesoxyeortieosterone, 18-hydroxycorticosterone and aldosterone in a dose-dependent manner. Canrenone dose-dependently reduces platelet-derived growth factor-induced cell proliferation and motility. Canrenone inhibits the activity of the Na+/H+ exchanger 1 induced by platelet-derived growth factor.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Aldadiene | NSC 261713 | SC-9376 | SC-14266

Quick Database Links

Gene Symbol

GR