Cannabisin F

SKU: orb2654782

Description

Melongenamides B-D and Cannabisin F have anti-inflammatory activity, they exhibit inhibitions of nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 values ranging from 16.2 to 58.5 uM.

Key Properties

• CAS Number: 163136-19-4
• MW: 624.69
• Purity: >98% (HPLC)
• Formula: C₃₆H₃₆N₂O₈

Bioactivity

• In Vitro:
  Cannabisin F (0~15 μM; 1 hour; BV2 microglia cells) inhibits the phosphorylation of IκBα, p65, but enhances the expression of Nrf2 and HO-1.Cannabisin F (0~15 μM; 24 hours; BV2 microglia cells) has no significant effect on cell survival, inhibits IL-6 and TNF-α production and their mRNA expression, inhibits the production of ROS and increases the expression of SIRT1. Cell Viability Assay Cell line: BV2 microglia cells. Concentration: 0~15 μM. Incubation time: 24 hours. Result: Had no significant effect on cell survival. Western blot analysis. Cell line: BV2 microglia cells. Concentration: 0~15 μM. Incubation time: 1 hour. Result: Inhibited the phosphorylation of IκBα, p65, but enhanced the expression of Nrf2 and HO-1.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only