Candesartan

SKU: orb1226373

Description

An angiotensin II receptor antagonist used mainly for the treatment of hypertension.Hypertension Approved(In Vivo):Candesartan (i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi) has neuroprotective effect, reducing neuronal injury, decreasing lesion volume and microglial activation, protecting CBF and improving functional behavior in a mouse model of TBI.

Key Properties

• CAS Number: 139481-59-7
• MW: 440.45
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₀N₆O₃
• SMILES: O=C(C1=C2N(CC3=CC=C(C4=CC=CC=C4C5=NNN=N5)C=C3)C(OCC)=NC2=CC=C1)O
• Target: Angiotensin Receptor
• Solubility: DMSO: 4.5 mg/mL (100 mM); Ethanol: 0.4 mg/mL (10 mM), with gentle warming （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vivo:
  Animal model: C57BL/6 mice (nine-week-old, male, 22–28 g). Dosage: 1 mg/kg. Administration: i.p.; 1 mg/kg/day; continuously for 1, 3 or 28 dpi. Result: Reduced the lesion volume after CCI injury by approximately 50%, decreased the number of dying neurons, lessened the number of activated microglial cells, protected cerebral blood flow (CBF), and reduced the expression of the cytokine TGF 1 while increasing expression of TGFB3.Showed good motor skills on the rotarod 3 days after injury, and improved performance in the Morris water maze 4 weeks after injury.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Candesartan, CV11974, CV-1197, CV 11974

Quick Database Links

Gene Symbol

Angiotensin Receptor