Candesartan

SKU: orb1308557

Description

Candesartan

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 139481-59-7
• MW: 440.47
• Purity: 98.30%
• Formula: C₂₄H₂₀N₆O₃
• SMILES: CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1
• Target: PPAR,RAAS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.27 mM);DMSO:4.5 mg/mL (10.22 mM)

Bioactivity

• Target IC50:
  AT1 receptor:0.26 nM
• In Vivo:
  In CHO-AT1 cells, Candesartan binds with high selectivity to the angiotensin II AT1 receptors. At a concentration of 0.1 nM, Candesartan can reduce the maximum constrictive response to angiotensin II. Additionally, in KU-19-19 cells, the introduction of Candesartan leads to an upregulation of VEGF and interleukin-8 expression, without affecting cell proliferation.
• In Vitro:
  In mice carrying KU-19-19 xenografts, Candesartan (10 mg/kg) reduced microvascular density and VEGF expression, inhibiting tumor cell growth. In WKY rats, a lower dose of Candesartan (0.5 mg/kg) decreased blood pressure and inhibited the binding of AT1 in various brain regions, including the subfornical organ, paraventricular nucleus of the hypothalamus, solitary tract nucleus, and the area postrema. Furthermore, in adult spontaneously hypertensive rats, Candesartan (0.3 mg/kg) reduced the infarct size, diminished severe ischemic lesions in the peri-infarct and subcortical areas, and lessened the decrease in cerebral blood flow.
• Cell Research:
  KU-19-19 cells are seeded at a cell density of 2 × 104 per well in 96-well plates and allowed to grow overnight. Then the cells are treated with various concentrations of Candesartan for various periods of time. Cell viability is determined by the Alamar Blue assay to examine the cytotoxicity and antiproliferative effect of candesartan. The absorbance value of each well is determined in a microplate reade(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CV 11974, CV11974, CV-11974, Candesartan, AT1 receptor, antihypertensive, angiotensin II AT1-Receptor, Angiotensin Receptor, inhibit, oral, hypertension, Inhibitor, hronic heart failure (CHF), Traumatic brain injury (TBI), PPAR-γ

Compound Identifiers

PubChem CID

2541