Camostat mesilate

SKU: orb1224533

Description

Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59721-29-8
• MW: 494.52
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₆N₄O₈S
• SMILES: CS(O)(=O)=O.CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(C=C2)N=C(N)N)C=C1
• Target: Sodium Channel
• Solubility: Water: 10 mg/mL (20.22 mM); DMSO: 99 mg/mL (200.19 mM)

Bioactivity

• In Vivo:
  Animal model: 6-8 week old female BALB/c mice (lethal SARS-CoV infection model). Dosage: 30 mg/kg. Administration: p.o. ; twice a day for 9 days. Result: Effective in protecting mice against death due to a lethal infection by SARS-CoV, with a survival rate of ～60%.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Foipan | FOY 305

Quick Database Links

Gene Symbol

Sodium Channel