Cambinol

• Catalog Number: orb1303297
• Category: Small Molecules
• Description: Cambinol
• CAS Number: 14513-15-6
• Purity: 98.47%
• MW: 360.43
• SMILES: OC1=C(CC2=C(NC(=S)NC2=O)C2=CC=CC=C2)C2=CC=CC=C2C=C1
• Formula: C₂₁H₁₆N₂O₂S
• Biological Activity: Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 > 300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
• Note: For research use only
• Expiration Date: 12 months from date of receipt.