Cambinol

SKU: orb1303297

Description

Cambinol is a cell-permeable SIRT1 and SIRT2 inhibitor with substrate-competitive activity, also functioning as a brain-penetrant neutral sphingomyelinase (N-SMase) inhibitor. It induces apoptosis in BCL6-expressing lymphoma cells via p53 and BCL6 hyperacetylation and is used in oncology and neurology research, including in vivo studies on exosome biology and cancer models.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 14513-15-6
• MW: 360.43
• Purity: 99.83% (May vary between batches)
• Formula: C₂₁H₁₆N₂O₂S
• SMILES: Oc1ccc2ccccc2c1Cc1c([nH]c(=S)[nH]c1=O)-c1ccccc1
• Target: Apoptosis,Sirtuin,Phospholipase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.55 mM);Ethanol:5 mg/mL (13.87 mM);DMSO:36 mg/mL (99.88 mM)

Bioactivity

• Target IC50:
  SIRT2:59 μM|SIRT1:56μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cambinol, Apoptosis, NSC112546, NSC-112546, Inhibitor, inhibit, NSC 112546, SIRT2, SIRT1, SIRT1/2 Inhibitor IV, Sirtuin, Phospholipase

Compound Identifiers

PubChem CID

3246390