Camalexin

SKU: orb1309879

Description

Camalexin is a phytoalexin from Camelina sativa with documented antifungal, antibacterial, and anticancer properties. Its mechanism involves the induction of reactive oxygen species (ROS), making it a valuable tool for studying plant defense and cancer cell apoptosis in vitro.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 135531-86-1
• MW: 200.26
• Purity: 99.84% (May vary between batches)
• Formula: C₁₁H₈N₂S
• SMILES: c1csc(n1)-c1c[nH]c2ccccc12
• Target: Antibacterial,Reactive Oxygen Species,Antifungal,ROS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (19.97 mM);DMSO:120 mg/mL (599.22 mM)

Bioactivity

• In Vitro:
  Camalexin exhibits antiproliferative activity against a human breast cancer cell line. For the oomycetes Phytophthora and Pythium, Nep1-like proteins trigger Camalexin synthesis and ROS formation, which are generally relevant for its formation. The esa1 mutant shows delayed Camalexin induction and reduced synthesis in response to ROS-inducing agents, confirming ESA1's crucial role, as evidenced by esa1 mutants' inability to synthesize Camalexin in response to Leptosphaeria maculans .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Fungal, Inhibitor, inhibit, antiproliferative, antifungal, antibacterial, anticancer, Bacterial, Camalexin, cruciferous, ROS, Reactive Oxygen Species, Phytoalexin, Reactive oxygen species (ROS)

Compound Identifiers

PubChem CID

636970