Calycosin-7-O-beta-D-glucoside

SKU: orb1225724

Description

Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycosin 7-O-β-D-glucoside is anticipated to be a promising anti-HIV agent. It shows scavenging activity to DPPH radicals, and superoxide anion . Calycosin 7-O-β-D-glucopyranoside possesses an alleviating effect on osteoarthritis and can increase the fluidity of brain cell membrane in ischemia-reperfusion rats. Calycosin 7-O-β-D-glucopyranoside possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity.(In Vitro):Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex.(In Vivo):Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia-reperfusion rat model.

Key Properties

• CAS Number: 20633-67-4
• MW: 446.4
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₂O₁₀
• SMILES: COC1=C(C=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O
• Target: MMP
• Solubility: Soluble in Pyridine, Methanol, Ethanol, etc.

Bioactivity

• In Vivo:
  Calycosin-7-O-β-D-glucoside (intraperitoneal injection; 26.8 mg/kg; 14 days) significantly reduces infarct volume, histological damage and BBB permeability in In vivo MCAO ischemia-reperfusion rat model. Animal model: Middle cerebral artery occlusion (MCAO) male adult Sprague-Daweley rats. Dosage: 26.8 mg/kg. Administration: Intraperitoneal injection; 26.8 mg/kg; 14 days. Result: Exhibited neuroprotective effects in rats.
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• In Vitro:
  Calycosin-7-O-β-D-glucoside (2 μM; 6 hours) remarkably inhibits the expression and activities of MMPs, and secures the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MMP