Caloxin 2A1

SKU: orb3053926

Description

Caloxin 2A1 is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 does not affect basal Mg2+-ATPase or Na+-K+-ATPase.

Key Properties

• CAS Number: 350670-85-8
• MW: 1478.55
• Purity: >98% (HPLC)
• Formula: C₆₄H₉₁N₁₉O₂₂
• Solubility: DMSO : ≥ 100 mg/mL (67.64 mM; )

Bioactivity

• In Vitro:
  Caloxin 2A1 inhibits Ca2+-Mg2+-ATPase in human erythrocyte leaky ghosts, but it does not affect basal Mg2+-ATPase or Na+-K+-ATPase in the ghosts or Ca2+-Mg2+-ATPase in the skeletal muscle sarcoplasmic reticulum. Caloxin 2A1 also inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate. Caloxin 2A1 increases airway smooth muscle cells (ASMCs) apoptosis.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only