Calcium Levofolinate

SKU: orb1221771

Description

Calcium Levofolinate, a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.(In Vivo):Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of 5-Fluorouracil.

Key Properties

• CAS Number: 80433-71-2
• MW: 511.5
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₁N₇O₇·Ca
• SMILES: C(=O)([C@@H](NC(=O)c1ccc(cc1)NC[C@@H]1N(c2c(=O)nc([nH]c2NC1)N)C=O)CCC(=O)[O-])[O-].[Ca+2]
• Target: Others
• Solubility: H2O : 26.5 mg/mL 51.81 mM

Bioactivity

• In Vivo:
  Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i. v. ; for 4 weeks) enhances the toxicity of 5-Fluorouracil. Animal model: Crj: CD(SD)BR rats (5 weeks). Dosage: 6, 20 or 60 mg/kg/day. Administration: i. v. ; for 4 weeks (combined with 10 mg/kg/day 5-Fluorouracil). Result: Decreased the RBC counts, increased extramedullary hematopoiesis and enhanced the suppression of lymphatic organs. Induced the potentiation in the toxicity of 5-Fluorouracil appeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-Fluorouracil.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Calcium levofolinate | CL307782

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