Calcipotriol

SKU: orb1308501

Description

Calcipotriol

Research Area

Metabolism Research

Key Properties

• CAS Number: 112965-21-6
• MW: 412.6
• Purity: 99.07%
• Formula: C₂₇H₄₀O₃
• SMILES: C[C@H](\C=C\[C@@H](O)C1CC1)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
• Target: Vitamin
• Solubility: DMSO:122.5 mg/mL (296.9 mM);Ethanol:50 mg/mL (121.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.69 mM)

Bioactivity

• Target IC50:
  GL261 cells:69.65 µM|HEK293/MRP1 cells:6.0 ± 1.8 μM
• In Vivo:
  METHODS: To study the antitumor activity of Diclofenac, Calcipotriol and Difluoromethylornithine, Diclofenac (100 μg/week), Calcipotriol (0.166 μg/week), calcipotriol (0.166 μg/week), The Difluoromethylornithine (463.3 μg/week) mixture was applied to the dorsal surface of mice once a day, five days a week for 17 weeks. RESULTS: Compared with the placebo group, the Diclofenac plus Calcipotriol group and Diclofenac plus DFMO plus Calcipotriol group showed significantly less weight gain.
• In Vitro:
  METHODS: HaCaT cells were treated with Calcipotriol (10⁻9 M, 10⁻⁷ M, and 10⁻⁵ M), and Western Blot was used to detect the expression levels of target proteins. RESULTS: IFN-γinduced K17 protein expression in HaCaT cells, and Calcipotriol dose-dependently inhibited this expression. 10⁻⁷ M and 10⁻⁵ M Calcipotriol inhibited K17 protein expression by 58.10% and 70.68%, respectively. METHODS: AsPC-1 cells were treated with 100 nM Calcipotriol, and Western Blot was used to detect the expression levels of target proteins. RESULTS: LRP6 protein levels were significantly decreased after Calcipotriol treatment.

Storage & Handling

• Storage: keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, MC903, MC-903, MC 903, Inhibitor, Calcipotriene, Calcipotriol, Vitamin D, Vitamin D receptor, VD/VDR

Compound Identifiers

PubChem CID

5288783