Cajanol

SKU: orb3211911

Description

Cajanol is an isoflavanone isolated from the roots of pigeon pea [Cajanus cajan (L.) Millsp.]. It inhibits cancer cell proliferation and induces apoptosis. Cajanol increases Bax expression, inhibits Bcl-2 expression, activates caspase-9 and caspase-3, induces PARP cleavage, arrests the cell cycle at the G2/M phase, generates ROS, disrupts mitochondrial membrane potential, and triggers cytochrome c release. Additionally, cajanol induces bacterial DNA damage, disrupts bacterial cell membranes, and exhibits antibacterial activity in vitro. It reduces PI3K expression, inhibits Akt and NF-κB phosphorylation, downregulates P-gp expression and transport function, restores sensitivity of resistant cancer cells to Paclitaxel, and suppresses the growth of Paclitaxel-resistant metastatic ovarian tumors. Cajanol is applicable in research related to breast cancer, ovarian cancer, and bacterial infections.

Key Properties

• CAS Number: 61020-70-0
• MW: 316.31
• Formula: C₁₇H₁₆O₆
• SMILES: O=C1C2=C(O)C=C(OC)C=C2OCC1C3=CC=C(O)C=C3OC
• Target: P-gp,Bcl-2 Family,Antibacterial,Akt,ROS,PARP,PI3K,NF-κB,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

P-gp,Bcl-2 Family,Antibacterial,Akt,ROS,PARP,PI3K,NF-κB,Apoptosis,Caspase