CAIX/XII/NAMPT-IN-1

SKU: orb3210275

Description

CAIX/XII/NAMPT-IN-1 is a triple inhibitor targeting carbonic anhydrase IX/XII (CAIX/XII) and nicotinamide phosphoribosyltransferase (NAMPT), with a Ki of 78.1 nM for hCA IX, a Ki of 64.4 nM for hCA XII, and an IC50 of 168 nM for hNAMPT. It induces apoptosis, promotes the accumulation of reactive oxygen species (ROS), inhibits the ERK/AKT signaling pathway, blocks DNA synthesis, and disrupts mitochondrial function. CAIX/XII/NAMPT-IN-1 exhibits antiproliferative effects on various cancer cells under both normoxic and hypoxic conditions. This compound is useful for cancer research, including studies on renal cancer, glioblastoma, and colorectal cancer.

Key Properties

• Target: Mitochondrial Metabolism,NAMPT,Akt,ERK,Apoptosis,ROS,Carbonic Anhydrase,DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Mitochondrial Metabolism,NAMPT,Akt,ERK,Apoptosis,ROS,Carbonic Anhydrase,DNA/RNA Synthesis