CAII/VII-IN-1

SKU: orb3173708

Description

CAII/VII-IN-1 is an orally active inhibitor of hCA II (KI= 12.3 nM) and hCA VII (KI= 22.6 nM), showing no significant activity towards hCA I. In vivo, it demonstrates excellent neuroprotective properties in a Pilocarpine-induced epilepsy model. It upregulates KCC2 and inhibits mTOR, contributing to its neuroprotective effects. CAII/VII-IN-1 exhibits no significant neurotoxicity or changes in liver and kidney function, making it a useful compound for epilepsy research.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3085155-69-4
• MW: 639.1
• Formula: C₂₇H₂₃ClN₈O₅S₂
• SMILES: O=C(NN=CC1=CN(N=C1C=2C=CC(Cl)=CC2)C3=CC=C(C=C3)S(=O)(=O)C)C=4N=NN(C5=CC=C(C=C5)S(=O)(=O)N)C4C
• Target: Na-K-Cl cotransporter,mTOR,Carbonic Anhydrase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Na-K-Cl cotransporter,mTOR,Carbonic Anhydrase