CADD522

SKU: orb1299025

Description

CADD522 (MFCD00167693) is a potent small molecule inhibitor that disrupts RUNX2-DNA binding with an IC50 of 10 nM. It exhibits antitumor activity and is a valuable research tool for studying RUNX2 function in cancer biology, bone metastasis, and osteosarcoma in both cellular and animal models.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 199735-88-1
• MW: 326.17
• Purity: 97.74% (May vary between batches)
• Formula: C₁₅H₁₃Cl₂NO₃
• SMILES: OC(=O)C1C2CC(C=C2)C1C(=O)NC1=CC=C(Cl)C(Cl)=C1
• Target: Reactive Oxygen Species,ROS,Others
• Solubility: DMSO:245 mg/mL (751.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.33 mM)

Bioactivity

• Target IC50:
  RUNX2:10 nM
• In Vitro:
  CADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding( IC50 of 10 nM), has antitumor activity

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reactive Oxygen Species, T47D-RUNX2, runt-related transcription factor-2 (RUNX2)-DNA, inhibit, MFCD00167693, MFCD-00167693, MFCD 00167693, Inhibitor, MDA-231, MDA-468, MCF7, CADD 522, CADD522, CADD-522, breast cancer

Compound Identifiers

PubChem CID

2834870