Cabozantinib hydrochloride

SKU: orb1302037

Description

Cabozantinib hydrochloride (XL184) is a multi-targeted tyrosine kinase inhibitor with potent activity against key receptors including VEGFR2, c-Met, Kit, Axl, and Flt4. It is widely used in preclinical research to investigate tumor angiogenesis, metastasis, and proliferation in both cellular assays and animal models of various cancers.

Research Area

Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1817759-42-4
• MW: 537.96
• Purity: 99.97% (May vary between batches)
• Formula: C₂₈H₂₅ClFN₃O₅
• SMILES: Cl.COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
• Target: FLT,c-Kit,c-Met/HGFR,ROR,VEGFR,Apoptosis,TAM Receptor
• Solubility: DMSO:5.38 mg/mL (10 mM)

Bioactivity

• Target IC50:
  FLT1:12 nM|RORα:172 nM (Ki)|VEGFR2:0.035 ± 0. nM|FLT4:6 nM|RORγ:111 nM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cluster of differentiation antigen 135, CD135, CD117, c-Kit, cKit, c-Met/HGFR, cMet/HGFR, cMet, c-Met, antiangiogenic, Apoptosis, angiogenesis, B16F10 cells, Axl, Cabozantinib, Cabozantinib hydrochloride, Cabozantinib Hydrochloride, Cabozantinib hydrochloride (849217-68-1(free base)), BMS 907351, BMS907351, BMS-907351, A431, Inhibitor, inhibit, Mer, HGFR, Fms like tyrosine kinase 3, HT1080, FLT4, FLT3, Tyro3, VEGFR2/KDR, VEGFR, Vascular endothelial growth factor receptor, RORγ, RORα, TAMReceptor, TAM Receptor, SCFR, XL 184, XL184, XL-184

Compound Identifiers

PubChem CID

122573030