Cabergoline

SKU: orb1308504

Description

Cabergoline is an ergot-derived dopamine D2-like receptor agonist with high affinity for D2, D3, and 5-HT2B receptors. It is widely used in research to study prolactinoma treatment, enabling effective hormonal and tumor control in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 81409-90-7
• MW: 451.6
• Purity: 99.92% (May vary between batches)
• Formula: C₂₆H₃₇N₅O₂
• SMILES: [H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@H](CN2CC=C)C(=O)N(CCCN(C)C)C(=O)NCC
• Target: Dopamine Receptor,Autophagy,5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.43 mM);DMSO:260 mg/mL (575.73 mM)

Bioactivity

• In Vivo:
  Cabergoline demonstrates a longer elimination half-life (63 to 109 hours) compared to other D2-like receptor agonists, offering prolonged clinical benefits from a single dose and potential enhancements in the quality of life for individuals with chronic conditions . It notably reduces the number of rapid eye movement (REM) sleep bouts in female mice, achieving a 67.3% reduction (F(1,11)=12.892, P=0.004) in non-restrained subjects, with the most considerable decrease observed during the dark phase (82.3% reduction). In male mice, Cabergoline significantly lowers baseline Prolactin (PRL) levels by 98.5% (F(1,6)=13.192, P=0.011) to 0.08 ng/mL within two hours post-injection. PRL levels normalize to baseline (5.0±0.60 ng/mL; F(1,6)=0.715, P=0.43) following a seven-day recovery period .
• In Vitro:
  Cabergoline(10 μM) is used to investigate its neuroprotective effects. MAP2 staining reveals that Cabergoline significantly suppresses the loss of neurons caused by H2O2 incubation. Pretreatment with Cabergoline inhibits H2O2-induced neuronal cell death in a dose-dependent manner. Cabergoline prevents apoptotic cell death following H2O2 exposure .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DopamineReceptor, Dopamine Receptor, Dopamine D3 receptor, Dopamine D2 receptor, Dopamine, D3, D2, 5HTReceptor, 5HT Receptor, 5-HT2B, 5-HT2B receptor, Autophagy, Cabergoline, FCE21336, FCE-21336, FCE 21336, Inhibitor, inhibit

Compound Identifiers

PubChem CID

54746