Cabazitaxel

SKU: orb1225866

Description

A semi-synthetic taxane and microtubule inhibitor for the treatment of hormone-refractory prostate cancer; possesses a favorable pharmacokinetic and safety profile, and a decreased propensity for P-glycoprotein (Pgp)-mediated drug resistance.Chemotherapeutic Agents Approved(In Vitro):The cytotoxicity of cabazitaxel (100 μg/mL) on 4T1 cells without irradiation is 70.8%. Cabazitaxel (100 μg/mL) exhibits a concentration-dependent antiproliferation effect, with the antiproliferative activity of 56.2%.(In Vivo):Cabazitaxel (10 mg/kg, i.v.) has certain toxicity to liver and kidney but it can be avoided by integrated into Ans. The body weights of mice treated with AN-ICG-CBX and AN-CBX have a slightly decrease, while body weights of the free CBX group significantly decrease compared to the control group.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 183133-96-2
• MW: 835.932
• Purity: >98% (HPLC)
• Formula: C₄₅H₅₇NO₁₄
• SMILES: O=C(O[C@@H]([C@@]1([H])[C@@]2(C)[C@@H](OC)C[C@@]3([H])OC[C@]31OC(C)=O)[C@]4(O)C[C@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)C5=CC=CC=C5)=O)C(C)=C(C4(C)C)[C@@H](OC)C2=O)C6=CC=CC=C6
• Target: Microtubule/Tubulin
• Solubility: DMSO: 93 mg/mL (111.3 mM); Ethanol: <1 mg/mL; Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Bioactivity

• In Vivo:
  Cabazitaxel (10 mg/kg, i. v.) has certain toxicity to liver and kidney but it can be avoided by integrated into Ans. The body weights of mice treated with AN-ICG-CBX and AN-CBX have a slightly decrease, while body weights of the free CBX group significantly decrease compared to the control group.
  Read more...
• In Vitro:
  The cytotoxicity of cabazitaxel (100 μg/mL) on 4T1 cells without irradiation is 70.8%. Cabazitaxel (100 μg/mL) exhibits a concentration-dependent antiproliferation effect, with the antiproliferative activity of 56.2%.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

XRP6258 | XRP 6258

Quick Database Links

Gene Symbol

Microtubule/Tubulin