CAB7-3

SKU: orb3174781

Description

CAB7-3 is an orally effective HBV capsid assembly modulator that demonstrates excellent antiviral potency. It inhibits HBVDNA with an EC50 of 70 nM and has a CC50 of 32.3 μM. The compound exhibits significant anti-HBV activity across various cell models, with EC50 values of 70 μM in HBV-integrated HepDES19 cells, 1 nM in tetracycline-induced HepAD38 cells, and 2 nM in HBV-infected HLCZ01 cells. In vivo, CAB7-3 effectively reduces hepatic HBV core protein levels and suppresses viral replication. It shows good drug-like properties and safety, making it suitable for hepatitis B virus research.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 3014372-17-6
• MW: 656.33
• Formula: C₂₈H₂₈BBrFN₅O₅S
• SMILES: C(OCC)(=O)C=1[C@@H](NC(=NC1CN2[C@@H](C(NC3=CC=C(B(O)O)C=C3)=O)CCC2)C4=NC=CS4)C5=C(Br)C=C(F)C=C5
• Target: HBV

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

HBV