C18:1 Ceramide (d18:1/18:1(9Z))

SKU: orb1694296

Description

C18:1 Ceramide (d18:1/18:1(9Z)) is a sphingolipid associated with metabolic disorders and cancer. Its levels are increased in insulin-resistant animal models and in the plasma and ovarian tissue of advanced ovarian cancer patients. This compound is utilized in metabolic and oncology research for in vitro and in vivo studies of lipid-mediated signaling pathways.

Research Area

Metabolism Research

Key Properties

• CAS Number: 5966-28-9
• MW: 563.94
• Formula: C₃₆H₆₉NO₃
• SMILES: CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC
• Target: Others
• Solubility: DMF:80 mg/mL (141.86 mM);Chloroform:4 mg/mL (7.09 mM)

Bioactivity

• In Vivo:
  Intravitreal injection of C18:1-Ceramide (1 μL, 10 μM) in a mouse optic nerve ischemia model improved structural integrity and reduced RGC apoptosis, supporting its neuroprotective potential in ischemic retinal injury.
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• In Vitro:
  Exogenous C18:1-Ceramide (5 μM, 24 h) significantly increased the survival of mouse primary retinal ganglion cells (RGCs) and reduced apoptosis induced by oxygen-glucose deprivation/reperfusion (OGD/R).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

C18:1-Ceramide, C18:1 Ceramide (d18:1/18:1(9Z)), C-18:1 Ceramide (d18:1/18:1(9Z)), C18:1 Ceramide (d18:1/18:1), Cer(d18:1/18:1(9Z)), Cer(d18:1/18:1)

Compound Identifiers

PubChem CID

5283563