C14-490

SKU: orb3022135

Description

C14-490 is an ionizable cationic lipid (pKa= 5.94) utilized in the synthesis of lipid nanoparticles (LNPs). These LNPs serve as a platform for subsequent gene editing studies in hematopoietic stem cells (HSCs) in utero. C14-490 LNPs encapsulate SpCas9 mRNA and TTR sgRNA, employing an optimized B5 formulation parameter, and are further enhanced by the surface attachment of CD45 antibody F(ab’)2 fragments to create Systemically Targeted Editing Mechanism LNPs (STEM LNPs).

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2639634-82-3
• MW: 1393.35
• Formula: C₈₆H₁₇₇N₅O₇
• SMILES: OC(CN(CCN1CCN(CC1)CC(OCC)CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC(OCC)CN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CCCCCCCCCCCC
• Target: Liposome

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Liposome