C14-4

SKU: orb2283478

Description

C14-4 (C14-494) is an ionizable lipid nanoparticle formulation designed for the efficient delivery of chimeric antigen receptor (CAR) mRNA into primary human T cells. This tool is utilized in both in vitro and in vivo research for advancing adoptive T cell therapies and immunology studies.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2639634-80-1
• MW: 1365.3
• Purity: 99.59% (May vary between batches)
• Formula: C₈₄H₁₇₃N₅O₇
• SMILES: OC(CN(CCOCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CCN1CCN(CCOCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC1)CCCCCCCCCCCC
• Target: Liposome
• Solubility: DMSO:80 mg/mL (58.6 mM);Ethanol:80 mg/mL (58.6 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (2.42 mM)

Bioactivity

• In Vitro:
  C14-4 (30 ng,48 h) promoted luciferase expression in Jurkat cells of primary human T cells by enhancing mRNA delivery with little cytotoxicity.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

C144, ​C14494​, ​C14-494​

Compound Identifiers

PubChem CID

164687424