C 87

SKU: orb1308508

Description

C 87 is a small molecule that directly inhibits TNF-α by binding to it, blocking TNF-α-induced cytotoxicity (IC50 = 8.73 μM) and downstream signaling. It is a useful research tool for studying TNF-α-mediated inflammatory and autoimmune pathways in both cellular and animal models.

Research Area

Cell Biology

Key Properties

• CAS Number: 332420-90-3
• MW: 502.932
• Purity: ≥98% (May vary between batches)
• Formula: C₂₄H₁₅ClN₆O₃S
• SMILES: [O-][N+](=O)C1=CC(N\N=C2C(=O)N(N=C\2C2=CC=CC=C2)C2=NC(=CS2)C2=CC=CC=C2)=CC=C1Cl
• Target: TNF
• Solubility: DMSO:5.06 mg/mL (10.06 mM)

Bioactivity

• Target IC50:
  TNF-α induced cytotoxicity:8.73 μM
• In Vivo:
  In mice, the level of alanine transaminase and aspartate transaminase is consistently reduced. C 87 markedly reduces injuries to the liver and improves animal survival. C 87 injection delays the incidence of death and increases the survival rate by two fo
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• In Vitro:
  C 87 reduces the activity of c-Jun N-terminal kinase (JNK) in L929 cells. C 87 prevents the degradation of IκBα in cells treated with TNF-α and potently blocks multiple signaling transduction pathways and downstream target gene activation triggered by TNF-α. C 87 exhibits good solubility and consistent dose-dependent functions in vitro. C 87 completely blocks the TNFα-induced activation of caspase-3 and caspase-8.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, C 87, C87, C-87, TNF Receptor, TNFR, TNFα-induced cytotoxicity, TNF-α, Tumor Necrosis Factor Receptor

Compound Identifiers

PubChem CID

4016403