Bz 423

SKU: orb1707503

Description

Bz-423 is a potent immunomodulatory small molecule that induces apoptosis via Bax/Bak activation, leading to mitochondrial outer membrane permeabilization and cytochrome c release. It has demonstrated partial efficacy in a murine lupus model, supporting its research use in studying autoimmune diseases and mitochondrial apoptosis pathways.

Research Area

Cell Biology

Key Properties

• CAS Number: 216691-95-1
• MW: 440.92
• Purity: 98.93% (May vary between batches)
• Formula: C₂₇H₂₁ClN₂O₂
• SMILES: CN1c2ccc(Cl)cc2C(=NC(Cc2ccc3ccccc3c2)C1=O)c1ccc(O)cc1
• Target: Bcl-2 Family,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.48 mM);DMSO:80 mg/mL (181.44 mM)

Bioactivity

• In Vitro:
  Bz-423 triggers the activation of Bax and Bak without concurrently activating ASK1/JNK in Ramos cells. The induction of apoptosis by Bz-423 in Ramos cells relies on superoxide, and it elicits a heightened superoxide response in these cells, resulting in the swift demise of Ramos B cells. In MEFs, Bz-423 rapidly elevates superoxide levels within 1 hour, with the extent of the increase depending on the concentration. In Ramos cells, Bz-423-induced superoxide generation instigates the activation of Bax and Bak, mediated by alterations in Mcl-1 expression and the functional activation of BH3-only proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bz 423, BZ 48, BZ48, BZ-48, Bax, Bak, Apoptosis

Compound Identifiers

PubChem CID

644335