BYK204165

SKU: orb1299404

Description

BYK204165 (RT-017290) is a potent small molecule inhibitor of PARP1, demonstrating an IC50 of 44.67 nM against the human recombinant enzyme. This compound is a valuable research tool for investigating DNA repair mechanisms in oncology, with applications in both in vitro cellular assays and in vivo preclinical cancer models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1104546-89-5
• MW: 252.27
• Purity: 99.61%
• Formula: C₁₅H₁₂N₂O₂
• SMILES: Cn1cccc1\C=C1\C(=O)NC(=O)c2ccccc12
• Target: PARP
• Solubility: DMSO:125 mg/mL (495.5 mM)

Bioactivity

• Target IC50:
  PARP1:44.67 nM|PARP1 (human):7.35 (pIC50)|PARP2 (mouse):5.38 (pIC50)
• In Vitro:
  BYK204165 displayed 100-fold selectivity for PARP-1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antitumor, BYK 204165, BYK204165, BYK-204165, Inhibitor, inhibit, PARP, RT 017290, RT017290, RT-017290, poly ADP ribose polymerase

Compound Identifiers

PubChem CID

66682134