BYBC-1

SKU: orb3210151

Description

BYBC-1 is a highly selective RNA G-quadruplex (G4) targeting ligand with strong affinity for the G4-RNAs of KRAS and NRAS (Kd=0.05-0.28 μM). By stabilizing the G4-RNA structures of KRAS and NRAS, BYBC-1 disrupts the PI3K/AKT and MAPK/ERK pathways, activates the DNA damage response (DDR), inhibits energy metabolism, and induces S phase arrest and apoptosis. It demonstrates high specificity for non-malignant fibroblasts and significantly suppresses the growth of HCT-116 xenografts in vivo. BYBC-1 is applicable for research related to colorectal cancer.

Key Properties

• CAS Number: 2563902-57-6
• MW: 495.43
• Formula: C₂₅H₂₃BrN₂O₂S
• SMILES: [Br-].O=C(O)C[N+]=1C=2C=CC=3C=CC=CC3C2C(C1C=C4SC=5C=CC=CC5N4C)(C)C
• Target: Akt,ERK,Apoptosis,PI3K,Ras,Caspase,DNA/RNA Synthesis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Akt,ERK,Apoptosis,PI3K,Ras,Caspase,DNA/RNA Synthesis