BX795

SKU: orb1224191

Description

BX795 is a potent and relatively specific PDK1 inhibitor with IC50 of 6 nM; also inhibits TBK1 and IKKε with IC50 of 6 nM and 41 nM; shows no activity for PKA, PKC, c-Kit, GSK3β, IKKα, IKKβ, etc.; blocks the autophosphorylation of overexpressed TBK1 and IKKepsilon at Ser-172; has no effect on the canonical NFkappaB signaling pathway.

Key Properties

• CAS Number: 702675-74-9
• MW: 591.4677
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₆IN₇O₂S
• SMILES: O=C(N1CCCC1)NC2=CC=CC(NC3=NC=C(I)C(NCCCNC(C4=CC=CS4)=O)=N3)=C2
• Target: PDK
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BX 795 | BX-795

Quick Database Links

Gene Symbol

PDK