BW-AQ-113

SKU: orb3175147

Description

BW-AQ-113 is a derivative of Anthraquinone that specifically degrades MDM2 and activates the p53 pathway. It exhibits IC50 values of 0.12 μM in Molt-4 cells and 0.2 μM in EU-1 cells. In p53-deficient K562 cells, p53-mutant T98G cells, and p53-inhibited HeLa cells, its IC50 values are 0.74, 5.2, and 2.1 μM, respectively. BW-AQ-113 induces apoptosis by downregulating the anti-apoptotic gene Bcl-2 and upregulating pro-apoptotic genes Bax and CASP3. Additionally, BW-AQ-113 can be utilized in research on hematologic malignancies with wild-type p53.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 1537900-10-9
• MW: 387.82
• Formula: C₂₀H₁₈ClNO₅
• SMILES: O=C1C=2C=CC=C(OCC)C2C(=O)C3=C(OCC)C=C(C=C13)NC(=O)CCl
• Target: Caspase,Bcl-2 Family,MDM-2/p53,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,Bcl-2 Family,MDM-2/p53,Apoptosis