BVT-14225

SKU: orb1225162

Description

A selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with IC50 of 52 nM; displays >200-fold selectivity over human and murine 11β-HSD2. reduces glucose levels in diabetic KKA(y) mice.Diabetes Preclinical.

Key Properties

• CAS Number: 376638-65-2
• MW: 401.9313
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₀ClN₃O₃S₂
• SMILES: O=C(N(CC)CC)CC1=CSC(NS(=O)(C2=CC=CC(Cl)=C2C)=O)=N1
• Target: 11β-HSD
• Solubility: DMSO: ≥ 27 mg/mL

Bioactivity

• In Vitro:
  Selective inhibition of 11β-HSD1 decreases blood glucose concentrations in hyperglycaemic mice. Selective inhibitors of 11β-HSD1 have considerable potential as treatments for a number of diseases of great unmet medical need such as type 2 diabetes, obesity and metabolic syndrome, a multifactorial disorder. BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC50 for 11β-HSD1 on a human enzyme assay of 52 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BVT14225 | BVT 14225

Quick Database Links

Gene Symbol

11β-HSD