BV02

SKU: orb1301175

Description

BV02 is a small molecule inhibitor of 14-3-3 protein-protein interactions. It is used in chronic myeloid leukemia research to disrupt cells harboring both wild-type and therapy-resistant T315I Bcr-Abl mutations, as demonstrated in various cellular studies.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 292870-53-2
• MW: 377.35
• Purity: 99.82% (May vary between batches)
• Formula: C₂₀H₁₅N₃O₅
• SMILES: Cc1c(N2C(=O)c3ccc(cc3C2=O)C(O)=O)c(=O)n(-c2ccccc2)n1C
• Target: Bcr-Abl,Others,Akt,PARP,Antibacterial,Apoptosis,Caspase,Autophagy
• Solubility: DMSO:10 mg/mL (26.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.65 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

14-3-3 protein-protein interaction, 2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid, BV 02, BV02, BV-02

Compound Identifiers

PubChem CID

1087337