Butyzamide

• Catalog Number: orb1741367
• Category: Small Molecules
• Description: Butyzamide
• Purity: 99.00%
• MW: 591.55
• Biological Activity: Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.
• CAS Number: 1110767-45-7
• Formula: C₂₉H₃₂Cl₂N₂O₅S
• SMILES: O(C)C1=C(C=CC=C1C(OCCC)C(C)(C)C)C=2N=C(NC(=O)C3=CC(Cl)=C(/C=C(/C(O)=O)\C)C(Cl)=C3)SC2
• Storage: -20°C
• Note: For research use only