Butyl chlorogenate

SKU: orb1737441

Description

Butylchlorogenate is a natural small molecule compound extracted from the plants Lonicera japonica and Urceola rosea. It is utilized in research for its potential biological activities, with studies investigating its effects in both in vitro assays and in vivo models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 132741-56-1
• MW: 410.42
• Purity: 99.62% (May vary between batches)
• Formula: C₂₀H₂₆O₉
• SMILES: C(OCCCC)(=O)[C@@]1(O)C[C@@H](OC(/C=C/C2=CC(O)=C(O)C=C2)=O)[C@H](O)[C@H](O)C1
• Target: Tyrosinase,Others
• Solubility: DMSO:4.11 mg/mL (10.01 mM)

Bioactivity

• In Vitro:
  Butyl chlorogenate were evaluated for their inhibitory activity against melanogenesis in α-MSH-stimulated B16 melanoma cells, five caffeoylquinic acids, i.e. Butyl chlorogenate exhibited inhibitory activities with 33-62% reduction of melanin content at 100 μM concentration with no or almost no toxicity to the cells (89-114% of cell viability at 100 μM). Western blot analysis showed that Butyl chlorogenate reduced the protein levels of microphtalmia-associated transcription factor (MITF), tyrosinase, tyrosine-related protein 1 (TRP-1), and TRP-2 mostly in a concentration-dependent manner, suggesting that this compound inhibits melanogenesis on α-MSH-stimulated B16 melanoma cells by, at least in part, inhibiting the expression of MITF, followed by decreasing the expression of tyrosinase, TRP-1, and TRP-2.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

12135130