Butoconazole

SKU: orb1685378

Description

Butoconazole is an imidazole-based antifungal compound used in research. It functions by inhibiting fungal ergosterol synthesis and is applied in studies of candidiasis, both in vitro and in animal models, to investigate antifungal mechanisms and efficacy.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 64872-76-0
• MW: 411.78
• Purity: 97.77% (May vary between batches)
• Formula: C₁₉H₁₇Cl₃N₂S
• SMILES: C(SC1=C(Cl)C=CC=C1Cl)(CN2C=CN=C2)CCC3=CC=C(Cl)C=C3
• Target: Antifungal
• Solubility: DMSO:77 mg/mL (186.99 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.86 mM)

Bioactivity

• In Vivo:
  Butoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.Butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

osmotic, inhibit, Inhibitor, ergosterol, Fungal, lanosterol, 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole, Antifungal, Butoconazole, cell, conversion, permeability

Compound Identifiers

PubChem CID

47472