Bupivacaine hydrochloride

SKU: orb1311005

Description

Bupivacaine hydrochloride is a long-acting amide local anesthetic that blocks neuronal sodium channels, inhibiting depolarization and producing reversible analgesia. It is widely used in research models for in vivo nerve block studies and in vitro electrophysiology experiments to investigate pain pathways and anesthetic mechanisms.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 18010-40-7
• MW: 324.89
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₂₈N₂O·HCl
• SMILES: Cl.CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
• Target: Potassium Channel,Sodium Channel,iGluR,Calcium Channel
• Solubility: DMSO:16.67 mg/mL (51.31 mM);H2O:21 mg/mL (64.64 mM);Ethanol:60 mg/mL (184.68 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.16 mM)

Bioactivity

• In Vivo:
  In vitro, Bupivacaine exhibits cytotoxic effects on bovine articular chondrocytes after an exposure of 15 to 30 minutes. It acts on isolated mitochondria as an uncoupler of oxygen consumption and adenosine diphosphate phosphorylation. Concentration-dependent mitochondrial depolarization and pyridine nucleotide oxidation are induced by Bupivacaine in these isolated mitochondria. Additionally, Bupivacaine triggers the opening of the permeability transition pore (PTP), a cyclosporin A-sensitive inner membrane channel pivotal in various forms of cell death.
• In Vitro:
  Bupivacaine can induce calcium release from the sarcoplasmic reticulum (SR) in rats and suppress the SR's uptake of calcium.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Vivacaine, SodiumChannel, Sodium Channel, Potassium Channel, electrophysiology, iGluR, Inhibitor, KcsA, inhibit, local, Ionotropic glutamate receptors, NMDA, Na+ channels, Na channels, pain, channel, anesthetics, Calcium Channel, Ca2+ channels, Ca channels, Bupivacaine, Bupivacaine HCl, Bupivacaine hydrochloride, Bupivacaine Hydrochloride

Compound Identifiers

PubChem CID

64737