Bufalin

SKU: orb1225012

Description

Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.

Key Properties

• CAS Number: 465-21-4
• MW: 386.52
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₄O₄
• SMILES: 5-((3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2H-pyran-2-one
• Target: ATPase
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Animal model: Forty male athymic BALB/c nu/nu mice (6-8 weeks old). Dosage: 0.1, 0.2, or 0.4 mg/kg. Administration: i.p. every day until 14 days. Result: Dose-dependently suppressed tumor growth.
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• In Vitro:
  Cell Viability Assay Cell line: NCI-H460 cells. Concentration: 0, 1, 2, 4 μM. Incubation time: 48 hours. Result: Decreased viability of NCI-H460 cells in a dose-dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 89595

Quick Database Links

Gene Symbol

ATPase