BTYNB

SKU: orb1298428

Description

BTYNB

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 304456-62-0
• MW: 309.18
• Purity: 99.91% (May vary between batches)
• Formula: C₁₂H₉BrN₂OS
• SMILES: NC(=O)c1ccccc1\N=C\c1ccc(Br)s1
• Target: NF-κB,c-Myc
• Solubility: DMSO:70 mg/mL (226.41 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.47 mM);Ethanol:4 mg/mL (12.94 mM)

Bioactivity

• Target IC50:
  IMP-1 c-Myc mRNA internation:5 μM (IC50)
• In Vitro:
  In cells, BTYNB downregulates several mRNA transcripts regulated by IMP1. BTYNB destabilizes c-Myc mRNA, resulting in downregulation of c-Myc mRNA and protein. BTYNB downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). The oncogenic translation regulator, eEF2, emerged as a new IMP1 target mRNA, enabling BTYNB to inhibit tumor cell protein synthesis. BTYNB potently inhibited proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells. Overexpression of IMP1 reversed BTYNB inhibition of cell proliferation. BTYNB completely blocked anchorage-independent growth of melanoma and ovarian cancer cells in colony formation assays. With its ability to target c-Myc and to inhibit proliferation of difficult-to-target melanomas and ovarian cancer cells, and with its unique mode of action, BTYNB is a promising small molecule for further therapeutic evaluation and mechanistic studies.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SK-MEL2, c-Myc, cMyc, BTYNB, BTYNB IMP1 Inhibitor, cancer cell, NF-κB, NFκB, NFkB, NF-kB, IMP1, MDK6620, MDK-6620, MDK 6620, IGROV-1, ES-2

Compound Identifiers

PubChem CID

721984