BTM-3528

SKU: orb1944425

Description

BTM-3528 is a research compound that activates the mitochondrial protease OMA1, triggering the integrated stress response via DELE1 cleavage and OPA1-dependent mitochondrial fragmentation. This mechanism leads to cell growth arrest and apoptosis, supporting its investigation as a potential anticancer agent in cellular models.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 2054998-45-5
• MW: 521.55
• Purity: 99.75% (May vary between batches)
• Formula: C₂₄H₁₉F₄N₃O₂S₂
• SMILES: O=C(O)C1=C(C=2C=CC=C(F)C2)C(=NN1C3=NC(=C(S3)SC(C)C)C=4C=CC(=CC4)C(F)(F)F)C
• Target: Mitochondrial Metabolism,Apoptosis,PERK

Bioactivity

• In Vivo:
  METHODS: BTM-3566 was tested in 9 human DLBCL patient-derived xenograft (PDX) models representing ABC and GCB DLBCL subtypes, treated with 20 mg/kg BTM-3566. RESULTS: All 3 mice in 6 of the 9 PDX models achieved CR, and when 27 mice from the treatment groups across the 9 models were combined, CR was observed in 66% (19/27), with an additional 4 mice experiencing partial remission (PR), 2 mice experiencing stable tumors, and 2 experiencing progressive disease.
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• In Vitro:
  Both BTM-3528 and BTM-3566 demonstrated potent, dose-dependent activity against DLBCL lines of varying genotypes, including MYC-rearranged (“double” and “triple” hit) lymphomas, with growth inhibition and IC >90%50 values ​​of 0.16–0.57 μmol/L.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BTM 3528, BTM3528, Apoptosis

Compound Identifiers

PubChem CID

124108518