BTK inhibitor 1 (Compound 27)

SKU: orb1694671

Description

Compound 27 is a potent and selective BTK inhibitor, demonstrating an IC50 of 0.11 nM against the enzyme and 2 nM for inhibiting B-cell activation in human whole blood assays. This small molecule is a valuable research tool for studying B-cell signaling and related autoimmune or hematological malignancies in both in vitro and in vivo models.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2230724-66-8
• MW: 474.49
• Purity: 99.96% (May vary between batches)
• Formula: C₂₄H₂₃FN₈O₂
• SMILES: FC=1C=C(C2=C3C(NC(=C3)C=4C=NN(C)C4)=NC=N2)C=CC1CNC(=O)C=5N=C(C(C)(C)C)ON5
• Target: BTK
• Solubility: DMSO:4.75 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  BTK (cell-free assay):0.11 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BTK inhibitor 1, BTK inhibitor 1 (Compound 27), BTK

Compound Identifiers

PubChem CID

90125978