BT173

SKU: orb1297778

Description

BT173 is a novel small molecule inhibitor targeting Homeodomain-Interacting Protein Kinase 2 (HIPK2). It attenuates renal fibrosis by suppressing the TGF-β1/Smad3 signaling pathway, as demonstrated in relevant in vitro and in vivo fibrosis research models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2232180-74-2
• MW: 382.21
• Purity: 98.24% (May vary between batches)
• Formula: C₁₈H₁₂BrN₃O₂
• SMILES: O(C)C1=CC2=C(C=C(C=N2)C3=NC(=NO3)C4=CC=C(Br)C=C4)C=C1
• Target: Others,DYRK
• Solubility: DMSO:Insoluble

Bioactivity

• In Vivo:
  In vivo, administration of BT173 decreased Smad3 phosphorylation and mitigated renal fibrosis and deposition of extracellular matrix in unilateral ureteral obstruction and Tg26 mouse models of renal fibrosis .
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• In Vitro:
  BT173 strongly inhibited the ability of HIPK2 to potentiate the downstream transcriptional activity of Smad3 in kidney tubular cells. Binding of BT173 to HIPK2 did not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. In vitro, treatment with BT173 inhibited TGF-β1–induced Smad3 phosphorylation and Smad3 target gene expression in human renal tubular epithelial cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HIPK2, BT 173, BT173, BT-173

Compound Identifiers

PubChem CID

135207342