BSJ-05-037

SKU: orb3210004

Description

BSJ-05-037 is a PROTAC-type protein degrader that targets ITK and can efficiently induce ITK protein degradation in T-cell lymphoma cell lines. By inhibiting ITK-related signal transduction, BSJ-05-037 blocks the activation of the NF-κB/GATA-3 pathway and reduces PLCγ1 phosphorylation levels, thereby suppressing tumor cell proliferation and enhancing their sensitivity to chemotherapy. It serves as an important tool molecule for studying the mechanisms underlying T-cell lymphoma and developing ITK-targeted therapeutic strategies.

Key Properties

• CAS Number: 2756388-01-7
• MW: 1022.20
• Purity: 99.26% (May vary between batches)
• Formula: C₅₁H₅₉N₉O₁₀S₂
• SMILES: O=C(NC1=NC=C(S1)SC2=CC(C(=O)N3CCN(C(=O)C)CC3)=C(OC)C=C2C)C4=CC=C(C=C4)N5CCN(CC5)CCCCCCCNC(=O)COC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8
• Target: Phospholipase,Tyrosine Kinases,PROTACs,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Phospholipase,Tyrosine Kinases,PROTACs,NF-κB